发明名称 |
CLEAR PHARMACEUTICAL AQUEOUS MICROEMULSION COMPRISING PROPOFOL AND PROCESS FOR PREPARATION |
摘要 |
The present invention concerns a clear pharmaceutical aqueous emulsion composition which comprises Propofol and a surfactant system and which is particularly usable for a safe administration through intravenous injection. A composition according to the invention is characterized in that said surfactant system comprises in combination at least one pharmaceutically acceptable monovalent metal salt of a fatty acid having from 5 to 23 carbon atoms, and at least one polyethylene glycol hydroxystearate. This combination allows to use a mass ratio (w/w) surfactant system / Propofol which is less than 4 and preferably less than or equal to 2.8, while obtaining such a clear composition.
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申请公布号 |
CA2657090(C) |
申请公布日期 |
2013.09.03 |
申请号 |
CA20052657090 |
申请日期 |
2005.07.08 |
申请人 |
PHYSICA PHARMA |
发明人 |
POUGNAS, JEAN-LUC;BROUSSAUD, OLIVIER;CALVET, NICOLAS;COMTAT, SOPHIE |
分类号 |
A61K9/107;A61K31/05 |
主分类号 |
A61K9/107 |
代理机构 |
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地址 |
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