发明名称 |
Alternative heterocycles for DNA recognition |
摘要 |
Methods and compositions are provided for forming complexes between dsDNA and novel oligomers comprising fused six-membered rings. By appropriate choice of target sequences and oligomers, complexes comprising oligomer-DNA are obtained with high association constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific genes.
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申请公布号 |
US8524899(B2) |
申请公布日期 |
2013.09.03 |
申请号 |
US20040794584 |
申请日期 |
2004.03.04 |
申请人 |
DERVAN PETER B.;BRIEHN CHRISTOPH A.;RENNEBERG DORTE;WEYERMANN PHILIPP;DOSS RAYMOND;MARQUES MICHAEL;CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
DERVAN PETER B.;BRIEHN CHRISTOPH A.;RENNEBERG DORTE;WEYERMANN PHILIPP;DOSS RAYMOND;MARQUES MICHAEL |
分类号 |
C07D235/18;C07D403/14;C07D471/04;C07D471/14;C07D473/02;C12N;C12Q1/68 |
主分类号 |
C07D235/18 |
代理机构 |
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地址 |
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