RNA oligomer, method for regulating the process of creation the miRNA and the use of RNA re oligomers as regulators of the miRNA formation process

摘要

The present invention relates to an RNA oligomer, methods for regulating ' a miRNA production process and RNA oligomers used as miRNA production process regulators. More precisely, the present invention relates to use of RNA oligomers disrupting a pre-miRNA structure as miRNA production process regulators. Oligomer interactions with a miRNA precursor (pre-miRNA) change the precursor' s secondary and tertiary structure. In consequence, the pre-miRNA is not specifically recognised and cleaved by the Dicer ribonuclease, and the specific miRNA is not produced.