INTERLEUKIN-21 RECEPTOR BINDING PROTEINS

摘要

THE PRESENT INVENTION PROVIDES BINDING PROTEINS AND ANTIGEN-BINDING FRAGMENTS THEREOF THAT SPECIFICALLY BIND TO THE HUMAN INTERLEUKIN-21 RECEPTOR (IL-21 R). THE BINDING PROTEINS CAN ACT AS, E.G., ANTAGONISTS OF IL-21R ACTIVITY, THEREBY MODULATING IMMUNE RESPONSES IN GENERAL, AND THOSE MEDIATED BY IL-21R IN PARTICULAR. THE DISCLOSED COMPOSITIONS AND METHODS MAY BE USED, E.G., IN DIAGNOSING AND/OR TREATING IL-21R-ASSOCIATED DISORDERS, E.G., INFLAMMATORY DISORDERS, AUTOIMMUNE DISEASES, ALLERGIES, TRANSPLANT REJECTION, CANCER, AND OTHER IMMUNE SYSTEM DISORDERS.