SIRTUIN MODULATING IMIDAZOHIAZOLE COMPOUNDS

摘要

PROVIDED HEREIN ARE NOVEL SIRTUIN-MODULATING COMPOUNDS AND METHODS OF USE THEREOF. THE SIRTUIN-MODULATING COMPOUNDS MAY BE USED FOR INCREASING THE LIFESPAN OF A CELL, AND TREATING AND/OR PREVENTING A WIDE VARIETY OF DISEASES AND DISORDERS INCLUDING, FOR EXAMPLE, DISEASES OR DISORDERS RELATED TO AGING OR STRESS, DIABETES, OBESITY, NEURODEGENERATIVE DISEASES, CARDIOVASCULAR DISEASE, BLOOD CLOTTING DISORDERS, INFLAMMATION, CANCER, AND/OR FLUSHING AS WELL AS DISEASES OR DISORDERS THAT WOULD BENEFIT FROM INCREASED MITOCHONDRIAL ACTIVITY. ALSO PROVIDED ARE COMPOSITIONS COMPRISING A SIRTUIN-MODULATING COMPOUND IN COMBINATION WITH ANOTHER THERAPEUTIC AGENT.