| 摘要 |
<p>Patent No. 595464 Disclosed is an isolated, alpha4beta7 heterodimer specific antigen binding protein having a heavy chain variable region comprising CDR1, CDR2 and CDR3 and a light chain variable region comprising CDR1, CDR2 and CDR3, wherein the variable regions are selected from the group consisting of: (a) a heavy chain variable region comprising CDR1, CDR2 and CDR3 from QVQLVQSGAEVKKPGASVKVSCKVSGYTVTDLSMHWVRQAPGKGLEWMGGFDPQDGETIYAQKFQGRVTMTEDTSTDTAYMELRSLRSEDTAVYYCTTESSSAWFDPWGQGTLVTVSS and a light chain variable region comprising CDR1, CDR2 and CDR3 from DIQMTQSPSSVFASVGDRVTITCRASQGISSWLAWYQQKPGKAPNLLIYGASSLQNGVPLFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPWTFGQGTKVEIK (b) a heavy chain variable region comprising CDR1, CDR2 and CDR3 from QVQLVESGGGLVKPGGSLRLSCAASGFTFSDYYMSWIRQAPGKGLEWLSYISNSGSAMYYADSVKGRFTISRDNARNSLYLQMNSLRAEDTAVYYCAREYSSGWFFFESWGQGTLVTVSS and a light chain variable region comprising CDR1, CDR2 and CDR3 from EIVMTQSPATLSVSPGERATLSCRASQSVSSNLVWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTDFTLTISSLQSEDFAVYYCQQYDDWPP; and (c) a heavy chain variable region comprising CDR1, CDR2 and CDR3 from QVQLVQSGAEVKKPGASVKVSCKVSGYTLSDLSIHWVRQAPGKGLEWMGGFDPQDGETIYAQKFQGRVTMTEDTSTDTAYMELSSLKSEDTAVYYCATGSSSSWFDPWGQGTLVTVSS, and a light chain variable region comprising CDR1, CDR2 and CDR3 from DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYGASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFANYYCQQANSFPWTFGQGTKVEIK.</p> |
