发明名称 |
A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN |
摘要 |
<p>597620 Disclosed herein is a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4); (b) converting the compound of formula (4) to a compound of formula (5) wherein Z' is hydrogen or a benzyl group; (c) converting the compound of formula (5) to naratriptan; and (d) optionally converting naratriptan to a salt thereof. Also disclosed herein are compounds (3) and (4) and processes for their preparation.</p> |
申请公布号 |
NZ597620(A) |
申请公布日期 |
2013.08.30 |
申请号 |
NZ20100597620 |
申请日期 |
2010.08.18 |
申请人 |
CIPLA LIMITED |
发明人 |
CHIKHALIKAR, SANDIP VASANT;KANKAN, RAJENDRA NARAYANRAO;GHAGARE, MARUTI;RAO, DHARMARAJ RAMACHANDRA |
分类号 |
C07D401/04;A61K31/404;A61K31/405 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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