SULFONYL COMPOUNDS WHICH SELECTIVELY MODULATE THE CB2 RECEPTOR

摘要

591111 Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. Compounds of formula (I) include: N-[3-((S)-2-Hydroxy-1,1-dimethyl-propyl)-isoxazol-5-yl]-2-methyl-2-(tetrahydro-pyran-4-sulfonyl)-propionamide, N -{ 3-[(3S)-3-hydroxy-2-methylbutan-2-yl]-1,2-oxazol-5-yl} -2-(1-methanesulfonylpiperidine-4-sulfonyl)-2-methylpropanamide, N-[1-Ethyl-5-(4-hydroxy-phenyl)-1H-[1,2,4]triazol-3-yl]-2-methyl-2-(tetrahydropyran-4-sulfonyl)-propionamide, N-[5-(4-Methoxy-phenyl)-2-methyl-2H-[1,2,4]triazol-3-yl]-2-methyl-2-(tetrahydro-pyran-4-sulfonyl)-propionamide, 2-Cyclopropylmethanesulfonyl-N -[1-ethyl-S-( 4-methoxy-phenyl)-1H-[1,2,4]triazol-3-yl]-2-methyl-propionamide, 2-methyl-2-{ 5-[2-methyl-2-(tetrahydro-pyran-4 -sulfonyl)-propionylamino]-isoxazol-3-yl} -propyl ester, N -[3-(1,1-Dimethyl-2-methylamino-ethyl)-isoxazol-5-yl]-2-methyl-2-( tetrahydropyran-4-sulfonyl)-propionamide, N-[3-(2-Hydroxy-1,1-dimethyl-ethyl)-isoxazol-5-yl]-2-methyl-2-[1-( tetrahydropyran-4-yl)-ethanesulfonyl]-propionamide, 2-Methyl-2-( 4,4,4-trifluoro-butane-1-sulfonyl)-propionic acid 2-methyl-2-{ 5-[2-methyl-2-( 4,4,4-trifluoro-butane-1-sulfonyl)-propionylamino ]-isoxazol-3-yl} -propyl ester and N-{ 3-[(3S)-3-hydroxy-2-methylbutan-2-yl]-1,2-oxazol-5-yl} -2-methyl-2-({ 2-[(3R)-oxolan-3-yl]ethane} sulfonyl)propanamide.