EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS

摘要

EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGSThe application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following. (I)