发明名称 |
8-SUBSTITUTED BENZOAZEPINES AS Toll-LIKE RECEPTOR MODULATORS, PHARMACEUTICAL COMPOSTION AND MEDICAMENT BASED THEREON, A METHOD OF TREATING A TLR7 AND/OR TRL8 MEDIATED CONDITION, A METHOD OF STIMULATING IMMUNE SYSTEM |
摘要 |
Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency. |
申请公布号 |
EA018543(B1) |
申请公布日期 |
2013.08.30 |
申请号 |
EA20080000634 |
申请日期 |
2006.08.17 |
申请人 |
ARRAY BIOPHARMA, INC. |
发明人 |
DOHERTY GEORGE, A.;EARY C., TODD;GRONEBERG ROBERT, D.;JONES ZACHARY |
分类号 |
C07D223/16;A61K31/55;C07D403/10 |
主分类号 |
C07D223/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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