| 摘要 |
A COMPOUND OF FORMULA (I) OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF: IN WHICH: X IS HALOGEN, CYANO, NITRO, OR C?-?ALKYL WHICH IS SUBSTITUTED BY ONE OR MORE HALOGEN ATOMS; Y IS SELECTED FROM HYDROGEN, HALOGEN, OR C?-?ALKYL; Z IS PHENYL, NAPHTHYL OR A RING A, WHERE A IS A SIX MEMBERED HETEROCYCLIC AROMATIC RING CONTAINING ONE OR TWO NITROGEN ATOMS OR MAY BE A 6,6 OR 6,5 FUSED BICYCLE CONTAINING ONE O, N OR S ATOMS OR MAY BE A 6,5-FUSED BICYCLE CONTAINING TWO O ATOMS, THE PHENYL, NAPHTHYL OR A RINGS ALL BEING OPTIONALLY SUBSTITUTED BY ONE OR MORE SUBSTITUENTS INDEPENDENTLY SELECTED FROM HALOGEN, CN, OH, NITRO, COR?, CO?R?, S0?R?, OR?, SR?, S0?NR��0R��, CONR��R��, NR��-R��, NHSO?R?, NR?SO?R?, NR?CO?R?, NR?COR?, NR?CONR?R?, NR?SO?NR?R?, PHENYL, OR C?-?ALKYL, THE LATTER GROUP BEING OPTIONALLY SUBSTITUTED BY ONE OR MORE SUBSTITUENTS INDEPENDENTLY SELECTED FROM HALOGEN; R� AND R� INDEPENDENTLY REPRESENT A HYDROGEN ATOM, OR A C?-?ALKYL GROUP R? AND R? INDEPENDENTLY REPRESENT HYDROGEN, C?-C? CYCLOALKYL OR C?-?ALKYL; R? INDEPENDENTLY REPRESENTS A HYDROGEN ATOM OR C?-C?ALKYL; R? IS C?-? ALKYL; R? REPRESENTS C?-?ALKYL, OPTIONALLY SUBSTITUTED BY ONE OR MORE SUBSTITUENTS INDEPENDENTLY SELECTED FROM HALOGEN OR PHENYL; R�� AND R�� INDEPENDENTLY REPRESENT PHENYL, A 5 MEMBERED AROMATIC RING CONTAINING TWO HETEROATOMS SELECTED FROM N OR S, HYDROGEN, C?-C? CYCLOALKYL OR C?-?ALKYL, THE LATTER TWO GROUPS BEING OPTIONALLY SUBSTITUTED BY ONE OR MORE SUBSTITUENTS INDEPENDENTLY SELECTED FROM HALOGEN OR PHENYL ; OR R�� AND R�� TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED CAN FORM A 3-8 MEMBERED SATURATED HETEROCYLIC RING OPTIONALLY CONTAINING ONE OR MORE ATOMS SELECTED FROM O, S(O)n (WHERE n = 0, 1 OR 2), NR?; PROVIDED THAT THE COMPOUND IS NOT [(5-CYANOBIPHENYL-2-YL)OXY]ACETIC ACID; [(5-NITROLBIPHENYL-2-YL)OXY]ACETIC ACID; [(2',4',5'-TRICHLORO)-4,5-(DICHLORO)-[1,1'-BIPHENYL]-2-YL]OXY]ACETIC ACID;[(3,5- DICHLORO[1,1'?BIPHENYL]-2-YL)OXY]-ACETIC ACID; [(5-CHLOROBIPHENYL-2-YL)OXY]ACETIC ACID; 2-[(3,5-DIBROMO[1,1'-BIPHENYL]-2-YL)OXY]-ACETIC ACID; OR 2-[(5-BROMO[1,1'-BIPHENYL]-2-YL-OXY]-ACETIC ACID; |
