Immunogenic composition comprising staphylococcal proteins

摘要

593693 Disclosed is the use of an immunogenic composition comprising: a) at least one isolated staphylococcal extracellular component binding protein or immunogenic fragment thereof selected from the group consisting of SdrG, laminin receptor, EbhA, EbhB, Elastin binding protein (EbpS), EFB (FIB), SBI, autolysin, ClfA, SdrC, SdrH, Lipase GehD, SasA, FnbA, FnbB, Cna, ClfB, FbpA, Npase, IsaA/PisA, SsaA, EPB, SSP-1, SSP-2, HBP, Vitronectin binding protein, coagulase and MAP; and c) at least one isolated staphylococcal toxin or immunogenic fragment thereof selected from the group consisting of alpha toxin (Hla) and alpha toxin H35R mutant; wherein said immunogenic fragments are capable of eliciting a protective immune response against Staphylococcal infection; in the manufacture of a vaccine for treatment or prevention of staphylococcal infection.