| 摘要 |
A metered dose inhaler actuator for pressurised aerosol containing a formulation of at least one medicament in a liquefied propellant gas. The actuator (2) comprises a nozzle block (5) having a bore (11) to receive a valve stem (7) - a sump (8) in connection with a bore (11), wherein the propellant formulation expands upon actuation of the inhaler, a nozzle channel (6), exiting from the sump (8) and aligned with a mouthpiece (4), wherein the sump has an internal volume less than 7 mmand greater than 5 mm, the bore (11) has a size suitable to receive a valve stem (7) having an internal volume comprised between 25 and 100 mmand the nozzle channel has a diameter between o,15 and 0,4 mm and channel length comprised between 0.7 and 0.4 mm to prevent the deposition of the medicament during the delivery into the chamber and/or into the nozzle channel. a reduction in the delivered dose, and an increase in the occurrence of the clogging of the inhaler. The actuator of the invention is particularly useful in the administration of pressurised metered dose inhaler formulations, in solution and/or in suspension, wherein the concentration of the active ingredient/s of the formulation is/are particularly high and in particular suitable to administer at least 100 mug/dose, preferably at least 200 mug/dose, even more preferably at least 400 mug/dose. |
