发明名称 |
PROGENITOR ENDOTHELIAL CELL CAPTURING WITH A DRUG ELUTING IMPLANTABLE MEDICAL DEVICE |
摘要 |
<p>A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.FIG. 1A</p> |
申请公布号 |
SG192440(A1) |
申请公布日期 |
2013.08.30 |
申请号 |
SG20130049721 |
申请日期 |
2006.11.15 |
申请人 |
ORBUSNEICH MEDICAL, INC. |
发明人 |
COTTONE, ROBERT, JOHN, JR.;ROWLAND, STEVEN, M.;PARKER, SHERRY;YOKLAVICH, MEG;KUTRYK, MICHAEL, JOHN, BRADLEY |
分类号 |
A61F2/91;A61F2/915;C12N5/074 |
主分类号 |
A61F2/91 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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