| 摘要 |
<p>The present invention relates to a phosphodiesterase 4 inhibitor capable of avoiding vomiting. Formula (I) represents a compound or a prodrug or a solvate, R1 is an independent methoxy, bromine and substituted aryl; X is an optionally substituted six-membered heterocyclic ring; Y is -(CH2)n-, -NH(CH2)n-, and -NH(CH2)n-0-, n being any value among 0, 1, 2, and 3; Z is an optionally substituted aromatic ring or an optionally substituted heteroaryl ring. The phosphodiesterase 4 inhibitor capable of avoiding vomiting involved in the present invention is a novel biphenyl series PDE4D inhibitor, and the inhibitor may be applied to treat depression and Alzheimer's disease, improve cognitive ability, and avoid adverse effects such as vomiting.</p> |
