Process for the Enzymatic Synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic Acid or Esters thereof, and Application in the Synthesis of Ivabradine and salts thereof

摘要

PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-3,4 DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-CARBOXYLIC ACID OR ESTERS THEREOF, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF Abstract A process for the enzymatic synthesis of the compound of formula (I): H3C-O s) H3C-O O Rio wherein R1 represents a hydrogen atom or an alkyl group, is disclosed. Also disclosed is its application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.