| 摘要 |
PROBLEM TO BE SOLVED: To identify therapeutic nucleoside analogs that can inhibit proliferation of cells such as cancer cells maintaining their telomeres either by telomerase and/or ALT mechanism.SOLUTION: Acyclic nucleoside analogs can interfere with telomerase activity and L-1 (LINE-1) retrotransposon encoded reverse transcriptase (L1RT) activity in proliferating cells (cancer cells (e.g., human cancer cells) ) at levels that are not cytotoxic to the corresponding normal somatic cells. |
