ANTIGEN-BINDING MOLECULE FOR PROMOTING DISAPPEARANCE OF ANTIGEN VIA FcgammaRIIB

摘要

The invention provides: an antigen-binding molecule containing (i) an antigen-binding domain for changing the binding activity in relation to an antigen depending on the conditions of ion concentration, (ii) an Fcgamma-binding domain having FcgammaRIIb selective binding activity, and (iii) an FcRn-binding domain having binding activity in relation to FcRn under the conditions of a pH acidic region; and a method for lowering the concentration of an antigen in the plasma in comparison with before administration of the molecule, the method comprising administering the molecule.