发明名称 |
FGF-18 Truncated Variants Having Increased Receptor Specificity And Uses Thereof |
摘要 |
The present invention relates to fibroblast growth factor 18 (FGF-18) variants having various truncations beyond the signal peptide domain of the N-terminus, which activate FGFR3 with increased specificity. The invention further relates to polynucleotides encoding the variants, pharmaceutical compositions comprising same and methods for use thereof in treating cartilage and skeletal disorders.
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申请公布号 |
US2013225493(A1) |
申请公布日期 |
2013.08.29 |
申请号 |
US201313848569 |
申请日期 |
2013.03.21 |
申请人 |
YAYON AVNER;ROM ERAN;SIRKIS ROY;STRAUSS-AYALI DALIT |
发明人 |
YAYON AVNER;ROM ERAN;SIRKIS ROY;STRAUSS-AYALI DALIT |
分类号 |
A61K38/18;A61K45/06;C07K14/50 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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