发明名称 Prodrugs of piperazine and substituted piperidine antiviral agents
摘要 This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
申请公布号 IL211961(A) 申请公布日期 2013.08.29
申请号 IL20110211961 申请日期 2011.03.27
申请人 BRISTOL-MYERS SQUIBB PHARMA COMPANY 发明人
分类号 A61K;A61K31/437;A61K31/496;A61K31/675;A61P;C07D;C07D471/04;C07F;C07F9/09;C07F9/572;C07F9/6561 主分类号 A61K
代理机构 代理人
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