(3,3-difluoropyrrolidin-1-yl)-((2s,4s)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)metanone, pharmaceutical compositions comprising same and use thereof in the manufacture of medicaments for treating conditions mediated by dipeptidyl peptidase iv

摘要

The invention provides compounds of formula (I), prodrugs and stereoisomers thereof, and the pharmaceutical acceptable salts of the compounds, prodrugs, and stereoisomers, wherein R 1 , R 2 , R 3 , HET, n, Q, X, Y and Z are as described herein; compositions thereof; and uses thereof in treating diabetic complications including diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, and the like.