| 摘要 |
PURPOSE: A hepatoprotection composition containing phlorotannins isolated from Ecklonia stolonifera or Ecklonia cava extract is provided to be used as a pharmaceutical composition for preventing and treating liver diseases. CONSTITUTION: A hepatoprotection composition which suppresses hepatocyte injury due to alcohol contains spirit extract of Ecklonia stolonifera or Ecklonia cava as an active ingredient. A health food composition for hepatoprotection contains the spirit extract of Ecklonia stolonifera or Ecklonia cava as an active ingredient. A pharmaceutical composition for hepatoprotection contains phlorotannin compounds as an active ingredient, isolated and purified from an ethyl acetate fraction of Ecklonia stolonifera or Ecklonia cava. The phlorotannin compounds are eckol, dieckol, dioxynodehydroeckol, phlorofucofuroeckol A, and phlorofucofuroeckol B. [Reference numerals] (AA) Ecklonia stolonifera and Ecklonia cava; (BB) Shade drying; (CC) Powder; (DD) Reflux extraction(repeat three times), using spirit; (EE) Extraction; (FF) Filtering at reduced pressure; (GG) Vacuum concentration, 40°C(removing organic solvent); (HH) Crude extract of Ecklonia stolonifera and Ecklonia cava; (II) Organic solvent soluble fraction(repeat 3-4 times); (JJ) N-hexane soluble extract; (KK) Water soluble fraction; (LL) Dichloromethane soluble extract; (MM) Water soluble fraction; (NN) Ethyl acetate soluble extract; (OO) Water soluble fraction |
