ANTIGEN BINDING MOLECULE THAT BINDS EGFR, VECTOR ENCODING THE SAME, AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide antigen binding molecules that bind EGFR, vectors encoding the same, and uses thereof.SOLUTION: The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human EGFR. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.