| 摘要 |
<p>The present invention relates to a bioimaging system using a nucleic acid-based nanobarcode, and more specifically, to: a bioimaging system of a novel concept in which a fluorescent material-labelled nucleic acid is contained inside an artificial lipid bilayer comprising a polymer matrix composed of poly(D,L-lactide-co-glycolide) inside a surface support composed of a lipid membrane; a preparation method thereof; and a use thereof. According to the present invention, the bioimaging system using a nucleic acid-based nanobarcode comprises a lipid membrane simulating a biomembrane so as to be stably introduced into cells in vivo, and can precisely transfer a nucleic acid-based nanobarcode to a target position by combining a target-specific nucleic acid aptamer to the surface of a lipid membrane, thereby remarkably increasing target-specific imaging efficiency. In addition, it is possible to remarkably lower toxicity in the body and to increase stability by forming a bilayer using biodegradable and biocompatible 50:50 poly(D,L-lactide-co-glycolide). Further, since drugs for treating various diseases can be freely contained inside the bioimaging system, the bioimaging system is expected to be a fundamental technology capable of being applied to both bio-diagnosis and therapy.</p> |
