发明名称 |
METHODS AND SYSTEMS FOR SIGNAL AMPLIFICATION OF BIOASSAYS |
摘要 |
Disclosed herein are methods and systems for the detection of an analyte of interest by an amplified assay. The method and systems of the invention utilize the high specificity of biomolecules that have been coupled to a solid support to further amplify a signal produced by the interaction of a binding agent with the analyte of interest as a means to detect low levels of the analyte of interest present in a sample. In certain embodiments, for immunochemical (for example, ELISA or RIA) or immunofluorescence assays in which a protein to be identified is bound directly or through capture antibodies to a passivated surface, amplification of ~10,000-fold can be achieved. |
申请公布号 |
WO2013126522(A1) |
申请公布日期 |
2013.08.29 |
申请号 |
WO2013US27060 |
申请日期 |
2013.02.21 |
申请人 |
LABORATORY CORPORATION OF AMERICA HOLDINGS |
发明人 |
ANDERSON, DWIGHT LYMAN;CONRAD, ANDREW J.;ERICKSON, STEPHEN ERIC;HOPKINS, BEN BARRETT |
分类号 |
C12Q1/70 |
主分类号 |
C12Q1/70 |
代理机构 |
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