METHOD FOR PREPARING 3-O-BENZYL-1,2-O-ISOPROPYLIDENE-Alpha-L-FURAN IDOSE

摘要

Provided is a method for preparing 3-O-benzyl-1,2-O-isopropylidene-alpha-L-furan idose, which comprises: (1) protecting hydroxyl of 3-O-benzyl-1,2-O-isopropylidene-alpha-D-glucofuranose (III) by benzoyl and methylsulfonyl to obtain 6-O-benzoyl-3-O-benzyl-1,2-O-isopropylidene-5-O-methylsulfonyl-alpha-D-glucofuranose (V); (2) subjecting the compound (V) to a cyclization reaction under an alkaline condition to obtain 5,6-epoxy-3-O-benzyl-1,2-O-isopropylidene-a-L-furan idose (VI); and (3) subjecting the compound (VI) to a ring-opening reaction to obtain 3-O-benzyl-1,2-O-isopropylidene-alpha-L-furan idose.