发明名称 |
MICROREACTOR AND METHOD FOR PREPARING A RADIOLABELED COMPLEX OR A BIOMOLECULE CONJUGATE |
摘要 |
A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.
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申请公布号 |
US2013225791(A1) |
申请公布日期 |
2013.08.29 |
申请号 |
US201113818569 |
申请日期 |
2011.08.25 |
申请人 |
REICHERT DAVID E.;KENIS PAUL J.A.;WHEELER TOBIAS D.;DESAI AMIT V.;ZENG DEXING;OENAL BIRCE C.;WASHINGTON UNIVERSITY IN ST. LOUIS |
发明人 |
REICHERT DAVID E.;KENIS PAUL J.A.;WHEELER TOBIAS D.;DESAI AMIT V.;ZENG DEXING;OENAL BIRCE C. |
分类号 |
C07K1/13;B01J19/00;C07B59/00;C07K1/107 |
主分类号 |
C07K1/13 |
代理机构 |
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