发明名称 |
Inhibitors of protein tyrosine kinase activity |
摘要 |
The invention relates to compounds of Formula (I) and their use for inhibiting protein tyrosine kinase activity In Formula (I), the group M is thieno[3,2,b]pyridinyl as shown, and the group D is a ring or ring system, and the groups Z, Ar, and G are as defined herein The invention relates particularly to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signalling, for example, the inhibition of VEGF receptor signalling and HGF receptor signalling The invention also provides compositions and methods for treating cell proliferative diseases and conditions, such as cancer, and for treating ophthalmic diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR). |
申请公布号 |
AU2008293038(B2) |
申请公布日期 |
2013.08.29 |
申请号 |
AU20080293038 |
申请日期 |
2008.08.28 |
申请人 |
METHYLGENE INC. |
发明人 |
RAEPPEL, STEPHANE;ISAKOVIC, LJUBOMIR;ZHOU, NANCY Z.;SAAVEDRA, OSCAR MARIO;RAEPPEL, FRANCK;CLARIDGE, STEPHEN WILLIAM;UNO, TETSUYUKI;GAUDETTE, FREDERIC;DEZIEL, ROBERT;ZHAN, LIJIE;MANNION, MICHAEL;VAISBURG, ARKADII |
分类号 |
C07D495/04;A61K31/00;A61K31/4365;A61P9/00;A61P27/02;A61P35/00 |
主分类号 |
C07D495/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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