发明名称 |
USE OF PI3K INIBITORS FOR THE TREATMENT OF OBESITY, STEATOSIS AND AGEING |
摘要 |
The first aspect of the invention relates to a phosphoinositide 3-kinase inhibitor for use in the treatment or prevention of a disease or condition associated with the expression of peroxisome proliferator-activated receptor gamma coactivator 1-± (Pgc1±) and/or uncoupling protein 1 (Thermogenin/Ucp1) in brown adipocytes. The disease or condition may be positive energy imbalance-associated, for example, obesity, an obesity-associated disease or condition, steatosis and biological aging (performance aging). Another aspect of the invention provides the use of a phosphoinositide 3-kinase inhibitor for promoting weight loss in an individual. |
申请公布号 |
EP2629771(A1) |
申请公布日期 |
2013.08.28 |
申请号 |
EP20110729141 |
申请日期 |
2011.06.01 |
申请人 |
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) |
发明人 |
PASTOR FERNANDEZ, JOAQUIN;MARTINEZ GONZALEZ, SONIA;SERRANO MARUGAN, MANUEL;BISCHOFF, JAMES R;ORTEGA MOLINA, ANA;OYARZABAL SANTAMARINA, JULEN |
分类号 |
A61K31/35;A61K31/4985;A61K31/5377;A61K45/06;C07D471/10;C07D487/04 |
主分类号 |
A61K31/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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