发明名称 |
MODULATORS OF P-SELECTIN GLYCOPROTEIN LIGAND 1 |
摘要 |
Multimeric compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The multimeric compounds and methods of the invention can be used to control unwanted T cell-or NK cell-mediated immune responses in conditions such as inflammatory diseases, autoimmune diseases, transplant rejection, and allerg ic diseases. |
申请公布号 |
ZA200602151(B) |
申请公布日期 |
2013.08.28 |
申请号 |
ZA20060002151 |
申请日期 |
2006.03.14 |
申请人 |
ABGENOMICS CORPORATION |
发明人 |
LIN RONG-HWA;CHANG CHUNG NAN |
分类号 |
A61K;G01N33/48;A61K39/395;A61K45/00;A61P35/00;A61P37/06;A61P37/08;A61P43/00;C07K16/28;C12Q1/02;G01N33/15;G01N33/50;G01N33/53;G01N33/577 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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