| 摘要 |
A compound comprising a C-type lectin Carbohydrate Recognition Domain (CRD) and an immunoglobulin Fc domain for use in treating or preventing a pathogen infection in a non-human, non-murine subject. Preferably the non-human, non-murine subject is not considered to be an immunocompromised or immunosuppressed subject. The non-human, non-murine subject may be a ruminant; a livestock; companion or racing animal. The CRD, immunoglobulin Fc domain and the non-human, non-murine subject may be bovine. The pathogen infection typically comprises infection by a bacterium, optionally Staphylococcus aureus or Streptococcus Uberis or Streptococcus Agalactiae/dysgalactiae. The subject (for example bovine subject) may have mastitis, subclinical mastitis, acute mastitis, chronic mastitis, high somatic cell count (high SSC), metritis or endometritis. The non-human, non-murine subject may typically be further administered an antibiotic or antifungal agent. The CRD may be from bovine Mannose binding Lectin (MBL) and the immunoglobulin Fc domain may be an IgG1 Fc domain. |
