| 摘要 |
FIELD: medicine.SUBSTANCE: there are presented: using (S)-5-aminomethyl-1-(5,7-difluoro-1,2,3,4-tetra-hydronaphth-2-yl)-2,3-dihydro-2-tioxo-1H-imidazole, (R)-5-aminomethyl-1-(5,7-difluoro-1,2,3,4-hydronaphth-2-yl)-2,3-dihydro-2-tioxo-1H-imidazole and a mixture thereof, as well as a pharmaceutically acceptable salts thereof, such as a hydrochloride salt (compound A, nepicastat) in a method of treating a patient suffering or prone to any symptom(s) of addiction, cocaine addiction or withdrawal, and using the compound A in the method of treating at least one phase of cocaine addiction specified in acquisition, maintenance, inhibition and recurrence. What is shown is: nepicastat significantly increased dopamine and the dopamine/norepinephrine in rat's brain, decreased norepinephrine, inhibited dopamine-?-hydroxylase in spontaneously hypertensive rats, with no effect on locomotor activity.EFFECT: nepicastat therapy of cocaine addiction has shown no significant deterioration of patient's mood, sleep and cognitive abilities.15 cl, 11 dwg, 33 ex |
