| 摘要 |
The present invention relates to a method for treating a subject having or at risk of a diabetes-related disorder. In a preferred embodiment, the method involves increasing the level or activity of Hypoxia Induced Factor 1 (HIF-1 alpha) in pancreatic-beta-cells or insulin-sensitive tissues in the subject by administering to the subject an inhibitor of a protein that decreases the level or activity of HIF-1alpha. The present invention also relates to a method of transplanting pancreatic islet cells in a subject.
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