发明名称 |
Modified clostridial toxins with enhanced translocation capability and enhanced targeting activity |
摘要 |
The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an enhanced targeting domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.
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申请公布号 |
US8518417(B1) |
申请公布日期 |
2013.08.27 |
申请号 |
US20070776043 |
申请日期 |
2007.07.11 |
申请人 |
STEWARD LANCE E.;FRANCIS JOSEPH;FERNANDEZ-SALAS ESTER G.;GILMORE MARCELLA A.;LI SHENGWEN;AOKI KEI ROGER;ALLERGAN, INC. |
发明人 |
STEWARD LANCE E.;FRANCIS JOSEPH;FERNANDEZ-SALAS ESTER G.;GILMORE MARCELLA A.;LI SHENGWEN;AOKI KEI ROGER |
分类号 |
A61K39/08;C12N1/20 |
主分类号 |
A61K39/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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