| 发明名称 |
Spiro-oxindole MDM2 antagonists |
| 摘要 |
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
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| 申请公布号 |
US8518984(B2) |
申请公布日期 |
2013.08.27 |
| 申请号 |
US20100945511 |
申请日期 |
2010.11.12 |
| 申请人 |
WANG SHAOMENG;YU SHANGHAI;SUN WEI;KUMAR SANJEEV;SUN DUXIN;ZOU PENG;MCEACHERN DONNA;ZHAO YUJUN;THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
WANG SHAOMENG;YU SHANGHAI;SUN WEI;KUMAR SANJEEV;SUN DUXIN;ZOU PENG;MCEACHERN DONNA;ZHAO YUJUN |
| 分类号 |
C07D487/10;A61K31/4015 |
主分类号 |
C07D487/10 |
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