Herein is reported the use of an immobilized non-covalent complex of a neonatal Fc receptor (FcRn) and beta-2-microglobulin (b2m) as affinity chromatography ligand in general and, for example, for the determination of the in vivo half-live of an antibody by determining the ratio of the retention times of the antibody and a reference antibody.
申请公布号
WO2013120929(A1)
申请公布日期
2013.08.22
申请号
WO2013EP52932
申请日期
2013.02.14
申请人
F. HOFFMANN-LA ROCHE AG;FALKENSTEIN, ROBERTO;HERTENBERGER, HUBERT;RUEGER, PETRA;SCHLOTHAUER, TILMAN