发明名称 |
Bioreactor for Isolation of Rare Cells and Methods of Use |
摘要 |
The present invention relates to a bioreactor apparatus, and methods of use, for the isolation of rare blood cells, including hematopoietic stem cells and megakaryocytes. The apparatus includes a soft substrate and an anti-contractility agent, thereby providing a soft microenvironment to cultured cells. The apparatus of the invention is permissive for the survival of non-dividing cells while dividing cells are eliminated. This unique property allows for the simple isolation of rare blood cells without the use of costly equipment and antibodies.
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申请公布号 |
US2013216506(A1) |
申请公布日期 |
2013.08.22 |
申请号 |
US201313772750 |
申请日期 |
2013.02.21 |
申请人 |
OF PENNSYLVANIA THE TRUSTEES OF THE UNIVERSITY;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
DISCHER DENNIS E.;SHIN JAE-WON |
分类号 |
C12M1/00;A61K35/14;A61K35/28;C12N5/078;C12N5/0789;C12Q1/68;G01N1/10;G01N33/569 |
主分类号 |
C12M1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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