| 摘要 |
PROBLEM TO BE SOLVED: To solve a problem that, though a lipocalin family has a pocket with a barrel structure, in other words, a cup-like shape, and can store a hardly water-soluble medicine in the same, in addition, a plurality of molecule units can be stored depending on the medicine, the pocket formed in the barrel structure has always opening, therefore, there is a risk of dropping the medicine already having been included during conveyance.SOLUTION: In using a lipocalin family as a capsule for a DDS, a pocket opening is brought to be capable of being closed with a disulfide crosslinking (S-S bond) after storing a medicine in the pocket formed in a barrel structure. To be concrete, enzyme activity of a lipocalin type prostaglandin D synthetase is deactivated and each of tryptophan residues at 34th and 92th positions from an N-terminal is substituted with a cysteine residue. |
