| 摘要 |
PURPOSE: A rheumatic or arthritic disorder treating composition which contains sphingosine 1-phosphate is provided to suppress various inflammatory factors. CONSTITUTION: A rheumatic or arthritic disorder treating composition comprises pharmaceutically acceptable carrier or diluent and sphingosine 1-phosphate as active ingredients. An inflammatory inducer is cyclooxygenase-2, inducible nitric oxide synthesis or NFkB(nuclear factor kB). The composition suppressing the chondrocyte inflammation contains pharmaceutically acceptable carrier or diluent and sphingosine 1-phosphate as active ingredients. The composition for treating the rheumatic or arthritic disorder contains pharmaceutically acceptable carrier or diluent and sphingosine 1-phosphate as active ingredients. The rheumatic or arthritic disorder is rheumatoid arthritis, degenerative arthritis, ankylosing spondylitis or osteoporosis. The composition which obstructs the inflammatory inducer contains pharmaceutically acceptable carrier or diluent and sphingosine 1-phosphate as active ingredients. |
