LNA ANTISENSE OLIGONUCLEOTIDES FOR THE MODULATION OF MYC EXPRESSION
摘要
The disclosure relates to oligonucleotide compounds (oligomers) that target Myc mRNA in a cell, leading to reduced expression of Myc. Reduction of Myc expression is beneficial for the treatment of certain disorders, such as hyperproliferative disorders (e.g., cancer). The disclosure provides therapeutic compositions comprising oligomers and methods for modulating the expression of Myc using said oligomers, including methods of treatment.
申请公布号
WO2013123451(A1)
申请公布日期
2013.08.22
申请号
WO2013US26515
申请日期
2013.02.15
申请人
ENZON PHARMACEUTICALS, INC.;DANA-FARBER CANCER INSTITUTE, INC.
发明人
BANDARU, RAJANIKANTH;ZHANG, YIXIAN;QU, ZHENGXING;GREENBERGER, LEE;OTT, CHRISTOPHER;BRADNER, JAMES ELLIOT