| 发明名称 |
METHOD FOR PREPARING LINEZOLID INTERMEDIATE |
| 摘要 |
Disclosed is a new method for preparing a methyl substitute of a linezolid intermediate, (S)-2-((3-(3-Fluoro-4-Morpholine phenyl)-2-oxy-5-oxazoline)) (I), wherein the intermediate (I) is obtained by the cyclisation of a 3-Fluoro-4-morpholine phenyl isocyanate (II) and epoxy compound (III). This process has a short route, low cost, easy operation, and high yield, so is suitable for large-scale industrial production. |
| 申请公布号 |
WO2013120448(A1) |
申请公布日期 |
2013.08.22 |
| 申请号 |
WO2013CN71576 |
申请日期 |
2013.02.08 |
| 申请人 |
ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.;SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY |
发明人 |
ZHANG, FULI;YANG, CHUNBO;LIANG, BIN;QIU, PENGCHENG;LUO, HAIRONG;LI, JIANG;CHAI, JIAN;CAI, QINGFENG |
| 分类号 |
C07D263/20;C07D205/12;C07D265/30;C07D295/155;C07D303/36;C07D413/00;C07D413/10 |
主分类号 |
C07D263/20 |
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