<p>The present invention is directed to a recombinant E. coli Nissle 1917 (EcN) cell transformed with a nucleic acid coding for a defensin protein or a derivative thereof. The invention is further directed to a pharmaceutical composition comprising this cell and a pharmaceutically acceptable carrier as well as a method of producing a recombinant E. coli Nissle 1917 cell and its use in the treatment of Crohn's disease.</p>
申请公布号
WO2013120618(A1)
申请公布日期
2013.08.22
申请号
WO2013EP00446
申请日期
2013.02.14
申请人
PHARMA-ZENTRALE GMBH
发明人
OELSCHLAEGER, TOBIAS;SEO, EAN, JEONG;WEHKAMP, JAN;STANGE, EDUARD, F.;SONNENBORN, ULRICH;MALINKA, JUERGEN;PROPPERT, HANS