| 发明名称 |
PEPTIDI IN GRADO DI DISSOCIARE LO ETERODIMERO MDM2/MDM4 E LORO USO NEL TRATTAMENTO DEL CANCRO. |
| 摘要 |
The present invention concerns peptides able to impair the inhibiting activity of MDM2/MDM4 heterodimer towards p53 and maintain the association between MDM4 and p53 so to restore the p53 oncosuppressive function in cancer cells harboring wild type p53 protein, directing its function specifically towards an apoptotic outcome. |
| 申请公布号 |
ITRM20120060(A1) |
申请公布日期 |
2013.08.22 |
| 申请号 |
IT2012RM00060 |
申请日期 |
2012.02.21 |
| 申请人 |
CONSIGLIO NAZIONALE DELLE RICERCHE;UNIVERSITA' DEGLI STUDI DI PERUGIA |
发明人 |
MACCHIARULO ANTONIO;MANCINI FRANCESCA;MORETTI FABIOLA;PELLEGRINO MARSHA;PELLICCIARI ROBERTO |
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