发明名称 4-Azetidinyl-1-phenyl-cyclohexane antagonists of CCR2
摘要 The present invention comprises compounds of Formula (I): wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
申请公布号 US8513229(B2) 申请公布日期 2013.08.20
申请号 US201113280690 申请日期 2011.10.25
申请人 ZHANG XUQING;HUFNAGEL HEATHER RAE;HOU CUIFEN;JOHNSON DANA L.;SUI ZHIHUA;JANSSEN PHARMACEUTICA NV 发明人 ZHANG XUQING;HUFNAGEL HEATHER RAE;HOU CUIFEN;JOHNSON DANA L.;SUI ZHIHUA
分类号 A61K31/397;C07D205/00 主分类号 A61K31/397
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