NEUROGENESIS OF MESENCHYMAL STEM CELLS ON THERMO SENSITIVE HYDROGEL AND COMPOSITION FOR NEURAL DIFFERENTIATION

摘要

PURPOSE: Neuronal differentiation of the mesenchyme stem cells is provided to be simply induced by using culture medium of the suitable composition and increase the mesenchyme stem cells without affecting the induction of being developed into the nerve cell. CONSTITUTION: Thermo-sensitivity supporter for the neural cell differentiation of the mesenchyme stem cell comprises a cell culture substrate; and thermo-sensitivity hydrogel which coated on the cell culture substrate. An obtaining method of nerve cell using the thermo-sensitivity hydrogel comprises a step of leading the thermo-sensitivity hydrogel as gel; a step of sowing the mesenchyme stem cells to the thermo-sensitivity hydrogel and developing it into neural progenitor cell; and a step of inducing the neural progenitor cell to the nerve cell. Composition for treatment of neurological disease comprises thermo-sensitivity hydrogel and nerve cell obtained by the attaining method.