A PROCESS FOR DETERGENT-FREE PRODUCTION OF OUTER MEMBRANE VESICLES OF A GRAM-NEGATIVE BACTERIUM
摘要
The present invention relates to the fields of medical microbiology and vaccines. In particular the invention relates to a process for detergent-free preparation of outer membrane vesicles (OMV) of Gram negative bacteria for use in vaccines, to OMV obtainable by said process, and to a pharmaceutical composition comprising such OMV. The present invention further relates to the use of OMV of the present invention as a medicament in particular for use in a method for eliciting an immune response.
申请公布号
WO2013006055(A8)
申请公布日期
2013.08.15
申请号
WO2012NL50478
申请日期
2012.07.05
申请人
DE STAAT DER NEDERLANDEN, VERT. DOOR DE MINISTER VAN VWS;VAN DE WATERBEEMD, BAS;VAN DER POL, LEONARDUS, ALDOLFUS
发明人
VAN DE WATERBEEMD, BAS;VAN DER POL, LEONARDUS, ALDOLFUS