发明名称 |
PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS |
摘要 |
The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone of Desoximetasone.
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申请公布号 |
US2013211069(A1) |
申请公布日期 |
2013.08.15 |
申请号 |
US201113811141 |
申请日期 |
2011.07.20 |
申请人 |
CHERNIAK SIMON;CYJON ROSA;OZER ILANA;NUDELMAN IGOR;TARO PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
CHERNIAK SIMON;CYJON ROSA;OZER ILANA;NUDELMAN IGOR |
分类号 |
C07J7/00;C07J71/00 |
主分类号 |
C07J7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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