Layout-aware modular decoupled crossbar and router for on-chip interconnects and associated micro-architectures and methods of operation. A crossbar and router architecture called MoDe-X (Modular Decoupled Crossbar) is disclosed that supports 5-port routing for use in 2D mesh interconnects and is implemented through use of decoupled row and column sub-crossbar modules in combination with feeder wiring and control logic that enables routing between ports on the row and column sub-crossbar modules. The corresponding MoDe-X router supports 5-port routing between various router input and output port combinations while reducing both router area and power consumption when compared with a conventional 5x5 crossbar design and implementation. The MoDe-X micro-architecture can be configured to support both single and dual local port injection configurations.