发明名称 |
Diagnostic BioMarkers for Fibrotic Disorders |
摘要 |
The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention also provides methods of assessing whether a subject has or is at risk of developing a fibrotic disorder by detecting levels of BMP9 and/or BMP10. Further provided are methods of assessing the efficacy of a treatment regimen for treating a fibrotic disorder by detecting and comparing pre-treatment levels of BMP9 and BMP10 with post-treatment levels of BMP9 and BMP10.
|
申请公布号 |
US2013209490(A1) |
申请公布日期 |
2013.08.15 |
申请号 |
US201313852079 |
申请日期 |
2013.03.28 |
申请人 |
BUCKLER ALAN;CHEN CHAO-MIN;GUY CHANTALE T.;HEWETT JEFFREY;LU CHRIS;WU JING;NOVARTIS AG |
发明人 |
BUCKLER ALAN;CHEN CHAO-MIN;GUY CHANTALE T.;HEWETT JEFFREY;LU CHRIS;WU JING |
分类号 |
A61K38/18;A61K31/7088;A61K38/16;A61K39/395;A61K45/06;G01N33/50 |
主分类号 |
A61K38/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|