发明名称 |
Engineering of immunoglobulin domains |
摘要 |
The present invention provides a single domain antibody (sdAb) scaffold comprising one or more than one non-canonical disulfide bond in the framework region (FR). The one or more than one non-canonical disulfide bond may be formed between cysteines introduced by mutations in FR2 and FR3. In the case where the sdAb scaffold is a V |
申请公布号 |
AU2012211011(A1) |
申请公布日期 |
2013.08.15 |
申请号 |
AU20120211011 |
申请日期 |
2012.01.27 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
KIM, DAE YOUNG;TANHA, JAMSHID |
分类号 |
C07K16/00;A61K39/395;C12N15/13;C40B40/10 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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